INHIBITION OF DCLK1 KINASE REVERSES EPITHELIAL-MESENCHYMAL TRANSITION AND RESTORES T-CELL ACTIVITY IN PANCREATIC DUCTAL ADENOCARCINOMA

Inhibition of DCLK1 kinase reverses epithelial-mesenchymal transition and restores T-cell activity in pancreatic ductal adenocarcinoma

Immunotherapy has recently become Video Cables a promising cancer therapy with extensive applications of immune checkpoint inhibitors (ICIs).However, pancreatic ductal adenocarcinoma (PDAC) appears to be unresponsive to immunotherapy due to the immunosuppressive microenvironment.Recent studies showed that cancer stem cell marker DCLK1 promoted the

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Genome sequences of two Salmonella enterica strains (MEZSAL74 and MEZSAL81) harbouring multiple antimicrobial resistance genes isolated from livestock in South Africa

Objectives: Antimicrobial-resistant livestock-associated Salmonella enterica infections pose a significant public-health threat Button Set worldwide.Here we report for the first time the draft genome sequences of two multidrug-resistant livestock-associated S.enterica strains isolated from a chicken and a cow in South Africa.Methods: Genomic DNA of

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Molecular structure, homo-lumo analysis and vibrational spectroscopy of the cancer healing pro-drug temozolomide based on dft calculations

The molecular structure and spectroscopic analysis of the Temozolomide molecule have been performed using the density Terminal Barriers functional theory in neutral and anion states as well as with the addition of DMSO solvent.The 6-311G(d) basis set was employed to optimize the molecular structure of the TMZ molecule using the DFT/B3LYP method.The

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Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein

The COVID-19 pandemic, once a global crisis, is now largely under control, a testament to the extraordinary global efforts involving vaccination and public health measures.However, the relentless evolution of SARS-CoV-2, leading to the emergence of new variants, continues to underscore the importance of remaining vigilant and adaptable.Monoclonal a

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